I did this purely in Photoshop for about 5 nights with my new Wacom tablet.
I wanted to make a new Ghost concept and at the same time practice with my tablet. So I created a different version of the original StarCraft Ghost. Aside from the standard Ghost arsenal, she packs a psi-blade reverse-engineered from Protoss tech.
Made in Adobe Photoshop CS5. The image shown here is half the original size. You can download for full-size.